Abnormal Structure-Function Relationship in Spasmodic Dysphonia

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Abnormal structure-function relationship in spasmodic dysphonia.

Spasmodic dysphonia (SD) is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. Although recent studies have found abnormal brain function and white matter organization in SD, the extent of gray matter alterations, their structure-function relationships, and correlations with symptoms remain unknown. We compared gray matter volume (GMV...

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Spasmodic dysphonia (SD) is a primary focal dystonia of unknown pathophysiology, characterized by involuntary spasms in the laryngeal muscles during speech production. We examined two rare cases of postmortem brainstem tissue from SD patients compared to four controls. In the SD patients, small clusters of inflammation were found in the reticular formation surrounding solitary tract, spinal tri...

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Tremor in speakers with spasmodic dysphonia

the objective of this work is the estimation of vocal tremor in patients with spasmodic dysphonia before and after treatment, and the comparison of their tremor characteristics with those estimated from healthy speakers. as an outcome, a new tremor attribute is introduced, the deviation of the modulation level and a novel method is proposed for classifying speakers according to the prevalence o...

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Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia.

Spasmodic dysphonia is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. The pathophysiology of spasmodic dysphonia is thought to involve structural and functional abnormalities in the basal ganglia-thalamo-cortical circuitry; however, neurochemical correlates underpinning these abnormalities as well as their relations to spasmodic d...

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Spasmodic dysphonia (SD) is a task-specific focal dystonia of unknown pathophysiology, characterized by involuntary spasms in the laryngeal muscles during speaking. Our aim was to identify symptom-specific functional brain activation abnormalities in adductor spasmodic dysphonia (ADSD) and abductor spasmodic dysphonia (ABSD). Both SD groups showed increased activation extent in the primary sens...

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ژورنال

عنوان ژورنال: Cerebral Cortex

سال: 2011

ISSN: 1047-3211,1460-2199

DOI: 10.1093/cercor/bhr120